ACADIA Pharmaceuticals Reports Promising Effects of Pimavanserin in Preclinical Model of Alzheimer’s Disease Psychosis
ACADIA scientists reported results of experiments using mice that had received intracerebroventricular (ICV) infusion of an amyloid β peptide fragment and developed Alzheimer’s disease-like pathology. These animals developed psychosis-like behaviors with enhanced responses to the psychostimulants DOI and amphetamine as well as disrupted prepulse inhibition. Treatment with pimavanserin prevented DOI-induced responses, reversed the augmented responses to amphetamine, and normalized prepulse inhibition in animals with amyloid pathology. These findings suggest that 5-HT2A antagonists/inverse agonists, such as pimavanserin, may be effective in the treatment of patients with ADP.
“ADP represents a major unmet medical need with no proven safe and effective therapy,” said Uli Hacksell, Ph.D., ACADIA’s Chief Executive Officer. “Physicians often resort to off-label use of antipsychotic medications in patients with ADP despite their association with increased mortality and potential worsening of cognitive disturbances. These new findings suggest that pimavanserin may be ideally suited to address the need for a new ADP treatment that is safe, effective and well tolerated.”
About Alzheimer’s Disease Psychosis
Alzheimer’s disease is a neurodegenerative disorder characterized by
progressive deterioration in cognitive functioning, memory
abnormalities, and a host of behavioral and neuropsychiatric symptoms.
According to the Alzheimer’s Association, 5.4 million people in
Pimavanserin is ACADIA’s proprietary small molecule that acts selectively as an antagonist/inverse agonist on serotonin 5-HT2A receptors and is in Phase III development as a potential first-in-class treatment for Parkinson’s disease psychosis. Pimavanserin can be taken orally as a tablet once-a-day. ACADIA discovered and holds worldwide rights to pimavanserin.
ACADIA is a biopharmaceutical company focused on innovative treatments
that address unmet medical needs in neurological and related central
nervous system disorders. ACADIA has four product candidates in clinical
development led by pimavanserin, which is in Phase III development as a
potential first-in-class treatment for Parkinson's disease psychosis.
ACADIA’s other clinical-stage products include collaborative programs
for chronic pain and glaucoma with
Statements in this press release that are not strictly historical in
nature are forward-looking statements. These statements include but are
not limited to statements related to the progress of ACADIA’s drug
discovery and development programs, either alone or with a partner, and
the benefits to be derived from ACADIA’s product candidates, including
in each case pimavanserin. These statements are only predictions based
on current information and expectations and involve a number of risks
and uncertainties. Actual events or results may differ materially from
those projected in any of such statements due to various factors,
including the risks and uncertainties inherent in drug discovery,
development and commercialization, and collaborations with others, and
the fact that past results of clinical trials may not be indicative of
future trial results. For a discussion of these and other factors,
please refer to ACADIA’s annual report on Form 10-K for the year ended
December 31, 2011 as well as ACADIA’s subsequent filings with the
ACADIA Pharmaceuticals Inc.
Uli Hacksell, Ph.D., Chief Executive Officer